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G37 2019 I DOC 611 /.018-dc23 LC record available at 2018040137 This work is provided "as is," and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. Identifiers: LCCN 2018040137 I ISBN 9781496396358 Subjects: LCSH: Histology-Outlines, syllabi, etc.
ECM BIOLOGY SERIES
I Philadelphia: Wolters Kluwer Health, I Series: Board review series I Includes index. Gartner, PhD, Professor of Anatomy (Retired), Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland. Title: Cell biology and histology/ Leslie P. Printed in China Library of Congress Cataloging-in-Publication Data To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at, or via our website at lww.com (products and services). government employees are not covered by the above-mentioned copyright. Materials appearing in this book prepared by individuals as part of their official duties as U.S. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Japanese translation, 2007, published by Medical Science International, LTD Greek translation, 2006 published by Parissianos Publishing Company Spanish translation, 2015, published by Wolters Kluwer Turkish translation, 2016, published by Istanul Tip KitabeviĪll rights reserved. Korean translation, 2005, published by ShinHeung Medscience, Inc. Seventh edition© 2015 Wolters Kluwer Health.
Senior Acquisitions Editor: Crystal Taylor Development Editor: Andrea Vosburgh Editorial Coordinator: Lauren Pecarich Marketing Manager: Michael McMahon Production Project Manager: David Saltzberg Design Coordinator: Stephen Druding Manufacturing Coordinator: Margie Orzech Prepress Vendor: S4Carlisle Publishing Services Eighth edition Copyright© 2019 Wolters Kluwer. Gartner, PhD Professor of Anatomy (Retired) Department of Biomedical Sciences University of Maryland Dental School Baltimore, Maryland and Histology EIGHTH EDITION Leslie P.This review summarizes the tumor ECM biology as it relates to drug delivery with emphasis on design parameters targeting the ECM.Ĭancer drug delivery extracellular matrix targeting tumor.Chapter 16 Digestive System: Oral Cavity and Alimentary Tract By capitalizing on the biology of the tumor microenvironment and the opportunities it presents for intervention, the ECM has been investigated as a therapeutic target, to facilitate drug delivery, and as a prognostic or diagnostic marker for tumor progression and therapeutic intervention. In particular, the ECM is implicated in invasiveness of tumors through its signaling interactions with cells. There are targets in the tumor-associated ECM at the level of signaling molecules, enzyme expression, protein structure, receptor interactions, and others. Because of its role in cancer etiology, the ECM holds opportunities for cancer therapy on several fronts. It is also highly involved in cancer progression. The extracellular matrix (ECM) plays an active role in cell life through a tightly controlled reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and other components.